Efficacy and function of Schisandra chinensis extract

Efficacy and function of Schisandra chinensis extract
Schisandra chinensis extract is the dried fruit extract of Schisandra chinensis, etc. Its main effective components are lignans such as Schisandra A, Schisandra B, Schisandra A, Schisandra B, Schisandra B, Schisandra B, Schisandra C, Schisandra ester Chemicalbook A, etc. It also contains many volatile oils such as pinene and organic acids such as citric acid, malic acid, tartaric acid, etc. It is used for chronic cough, asthenic asthma, nocturnal emission, semen slippery, enuresis, frequent urination, persistent diarrhea, spontaneous sweating and night sweating, fluid injury and thirst, shortness of breath, pulse deficiency, internal heat and thirst, palpitation and insomnia.
pharmacological action
1. Effect on liver
Schisandra chinensis extract and its preparation can promote the heterogenesis of liver glycogen and the decomposition of liver glycogen, and strengthen the glucose phosphorylation process of fructose in brain, liver and muscle; Its ethanol extract can significantly reduce serum alanine aminotransferase and has protective effect on liver damage caused by carbon tetrachloride. After intragastric administration of Schisandrin (I) in rats, the activities of liver microsomal cytochrome P-450, NADPH-cytochrome C reductase, aminopyrine demethylase, liver weight and liver microsomal protein content were significantly increased, and the activity of benzo specific hydroxylase was increased. The electron microscope observation showed that the smooth endoplasmic reticulum of rat liver cells was significantly increased, indicating that it had an induction effect on liver microsomal monooxygenase. In addition, it can reduce the SGPT of CCl4 poisoned mice, inhibit the liver microsomal lipid peroxidation caused by CCl4, and the metabolism of CCl4 into CO. These effects are similar to those of other components of Schisandra chinensis, such as B, etc.
2. Effect on central nervous system
Schisandra chinensis extract can increase the excitability of the central nervous system, improve intellectual activity and work efficiency. Schisandra chinensis can significantly prolong the sleep time of mice on pentobarbital sodium, and the two have synergistic effects. Oral administration of pentanol in mice can significantly reduce brain activity. Its alcohol extract has the effect of anti-shock and convulsion caused by central stimulant.
3. Effect on gastrointestinal ulcer
Schisandra chinensis extract has a good effect on inhibiting gastric ulcer and preventing gastric mucosal damage caused by anhydrous ethanol.
4. Impact on cardiovascular system
Schisandra chinensis and its extract have vasodilation effect, and have significant pressor effect when circulation fails. In addition, it also has a certain cardiotonic effect. Schisandra chinensis has effects on isolated and in vivo frog heart β Role of receptor blockers.
5. Effect on immune system
The inhibitory effect of Schisandra chinensis seed alcohol extract (25mg/kg/day) on mouse spleen antibody secreting cells and specific rose-forming cells was the same as that of corticosteroid (20mg/kg/day), and the combination of the two had obvious synergistic effect.
6. Anti-aging effect
Schisandra chinensis extract can enhance cellular immunity, strengthen the synthesis of RNA and PAS in testis and ovary, promote the proliferation of germ cells, have obvious anti-free radical effect, and also play an anti-aging role by changing MAO and its isoenzyme activity. Schisandrin has antioxidant effect and can protect the heart from the damage of lipid peroxidation.
7. Effect on kidney
Gomicin A and deoxyschizandrin can inhibit the increase of urinary protein excretion and improve serum biochemical indicators.
8. Anti-allergic effect
Gomicin A has obvious inhibitory effect on the passive allergic skin reaction (PCA) of rats and the skin allergic reaction of rats.
9. Antitumor effect
Schisandra chinensis extract γ- Schisandrin has cytotoxic effects on leukemia and KB cells, and has inhibitory effects on the metabolism of DNA, ATP and nuclear protein in cancer cells.
10. Antimicrobial effect
100% aqueous solution is the most sensitive to dermatophytes. The ethanol extract of Schisandra chinensis has inhibitory effect on Bacillus anthracis, Staphylococcus aureus, Staphylococcus albus, Bacillus paratyphi A and B, Bacillus pneumoniae, Bacillus typhimurium, Vibrio cholerae, Salmonella enteritidis, Shigella dysenteriae, and Bacillus mutans in vitro. It also has strong antibacterial effect on Pseudomonas aeruginosa. It has antiviral effect in vivo and in vitro.
11. Toxic and side effects
Schisandra chinensis has very little toxicity, and no toxicity was found after 5 g/kg of extract was given to mice by gavage. There was no death after administration of schisandrin 1 g/kg. There are also reports of dyspnea caused by taking schisandra decoction and skin allergy caused by schisandra syrup.